Mesenchymal Stem Cell

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What are MSC?

Mesenchymal stem cells (MSCs) is a special type of multipotent stem cells able to repair or replace damaged cells, reduce cell and tissue inflammation, stimulate regeneration of senile cells and delay aging of healthy cells.

Why are Mesenchymal Stem Cells (MSCs) Special?

Immune neutral (no blood type match is required) and hence MSCs can be obtained from one donor and be given to another recipient. i.e. allogenic, confirmed from numerous clinical trials to have absolutely no side effects/tissue rejection. Safe for everyone.
MSCs are effective even in its undifferentiated state through its secretions.
Absolutely 0% cancer risk confirmed from many human clinical trials from the past 15 years.

Other stem cells require blood type match to avoid side effects/tissue rejection. Allogenic use of stem cells without blood type match may not be safe for everyone.
Other stem cells must be differentiated into the desired cell type and delivered to the correct location to be effective.
Other stem cells (e.g. embryonic stem cells, induced pluripotent stem cells (iPSCs)) develop into cancer.

MSC Mechanism of Action

MSC regenerate the human body in 2 ways:

Mechanism #1： Secretion of a complex repertoire of healing and anti-inflammation factors into bloodstream and circulate throughout the entire body, exerting anti-aging effects directly on your cells and indirectly by stimulating your own stem cells everywhere in your body.

Mechanism #2：MSC can self navigate towards damaged sites in your body and replace damaged cells by differentiating into type of cell required for replacement.

MSC Therapy

MSC Therapy (Anti-aging)

MSC Therapy (Anti-Aging) involves infusion of MSCs and using the blood distribution to circulate MSCs and their secretions throughout the body, awakening your own dormant stem cells, enhance cell to cell communications, improve cell activity, delay cell death and reduce inflammation.

MSC Therapy (Osteoarthritis)

MSC Therapy (Osteoarthritis) involves intra-articular injection of MSCs to confine the MSCs within the knee cap

MSC secretions reduce pain and inflammation, and trigger repair of the cartilage cells. MSC can convert themselves into cartilage cells, reversing the age of the knee, making it younger.

Age reversal of knee joint

Source of MSCs

MSCs can be obtained by puncturing the bone and sucking out the bone marrow, which contains some MSCs. But the procedure can be painful and quantity is quite limited. MSCs can also be obtained by liposuction from fat tissues. Although large quantities of fats are extracted, only a small fraction contains MSCs. Liposuction is a surgery that requires anesthesia (relatively risky and requires post-surgery recovery time).

While using MSCs extracted from your own body is an attractive idea, the extraction procedures can create discomfort and inconvenience. Moreover, MSCs derived from either bone marrow or fat tissues require young donors to achieve sufficient potency and quantity. Using your own MSCs when you are above certain age may not lead to expected benefits

Umbilical cord is a rich source of MSCs and generated as a medical waste and can be ethically obtained. Umbilical cord samples is obtained without any risk or pain to both the mother and baby.

MSCs obtained from umbilical cord is also the youngest (Age 0) and hence the most potent. MSCs obtained from adult bone marrow and fat tissue are older and hence less potent.

Are you getting the BEST MSCs?

Manufacturing Process

We use proprietary method developed in collaboration with local hospital to isolate, expand and cryo-store umbilical cord derived MSCs that ensures highest cell potency and full traceability of source.

Personnel

Our production and QC specialists have broad and deep experience specifically in MSC manufacturing.

Unique source of material

Umbilical cords donated from local hospitals are subjected to Enhanced Human Tissue Banking Service Regulations by Health Science Authority of Singapore# .
Umbilical cords are superior in quality due to affluent Singapore population and blue zone designation*.
Materials used in production are of the highest quality: 100% xeno-free (no animal components), 100% serum free, GMP grade and completely traceable records.
Stringent donor screening requirements for infectious diseases: Hepatitis B virus, Hepatitis A virus, Human immunodeficiency virus (HIV), Syphillis and venereal disease, Cytomegalovirus, Human T-cell lymphotrophic virus (HTLV) types I and II.
Comprehensive donor medical history checks for non-infectious diseases: recent hospitalizations, genetic disease, family medical history.

# – Health Science Authority is the first agency in the world to be designated World Health Organization (WHO)-Listed Authority.
* – https://www.bluezones.com/2023/10/the-worlds-6th-blue-zones-region/

Quality Control and Quality Assurance

Meets and exceeds standards set by International Society for Cell and Gene Therapy (ISCT).
Detailed documentation of cell data to ensure highest potency and consistency.
Stringent sterility, environmental and safety standards, according to Singapore’s Cell & Gene Therapy Regulations 2021